Investigating non-invasive neurostimulation alongside language instruction and therapy.

We pair an investigational electrical brain stimulation protocol with the language instruction which learners are already practicing. The outcomes we measure: decoding unfamiliar words, acquiring new vocabulary, and retention after treatment ends.

From the published literature

Findings from peer-reviewed tES trials.

The findings below describe effects observed in past studies of tES (transcranial electrical stimulation). They are the load-bearing prior work for the research we run.

11 / 11
Eleven published dyslexia trials, all reporting reading improvement

A 2025 scoping review of every published tES clinical trial in developmental dyslexia found positive effects on reading in all eleven, with the strongest, most consistent signal on novel-word decoding, the core skill at the center of the condition.

Constantino et al., CoDAS (2025)
+40%
Faster vocabulary acquisition in a 2014 RCT

In a randomized five-day trial, adults who trained with tES learned up to 40% more novel vocabulary than an unstimulated control. Results persisted after the study ran.

Meinzer et al., Cortex (2014)

Our mission

Build the evidence that brain stimulation can accelerate language learning, whether it's a child decoding their first words or an adult mastering their fifth.

The science, in plain English

A nudge to the brain's circuits that do the work.

Our devices deliver a small electrical current, roughly the strength of a hearing-aid battery, through two electrodes on the scalp. It isn't strong enough to fire neurons on its own. The tES literature describes the effect as lowering the threshold for firing: the region under the electrode appears to become a little more responsive to whatever it's already trying to do.

Which is why the instruction matters more than the device. We pair the current with active practice (sounding out words, learning new vocabulary) so that the circuits doing that work are engaged at the moment of stimulation. Whether that pairing translates into faster learning, and by how much, is the question each pilot is designed to answer. Stimulation on its own doesn't teach anyone anything.

Different jobs, different targets. For reading and phonics, we target several regions in the system that turns letters into sounds, the network a struggling reader leans on when they meet an unfamiliar word. For language learning, Broca's and Wernicke's areas, the brain's talker and its listener.

Dive into the research

Read the papers.

Major studies from the tES (transcranial electrical stimulation) literature in reading and language acquisition.

PRISMA flow diagram showing 11 clinical trials included from 30 identified records

Every published tES trial in dyslexia improved reading

A 2025 scoping review of the entire tES-for-developmental-dyslexia clinical literature (225 participants total). Strongest, most consistent signal on non-word decoding.

Constantino et al., CoDAS (2025)
Read the paper
Bar charts showing active tES outperforming sham on low-frequency word and non-word reading across four timepoints

Reading gains held six months after treatment

Eighteen sessions of tES paired with phoneme-grapheme training produced low-frequency word and pseudoword reading gains that persisted at six-month follow-up.

Costanzo et al., Neuropsychologia (2019)
Read the paper
Learning curves across five training days plus one-week follow-up showing active tES learners outperforming sham on familiar and novel object naming

Faster novel vocabulary acquisition in adults

In a randomized five-day trial (n=40), adults trained with tES over left temporoparietal cortex learned up to 40% more novel vocabulary than sham controls.

Meinzer et al., Cortex (2014)
Read the paper
Brain rendering showing Broca's and Wernicke's areas alongside an EEG cap montage used for stimulation

Large-scale replication in 160 Russian speakers

tES over core left-hemisphere language areas facilitated novel word acquisition, with the largest gains for anodal stimulation of Broca's area.

Shtyrov et al., Neurobiology of Learning and Memory (2024)
Read the paper
Forest-plot-style summary showing pooled effect g=0.50 with 95% CI [0.29, 0.71] across nine trials

Moderate, reliable gains across nine language-learning trials

A 2021 systematic review and meta-analysis of tES trials for second- and foreign-language learning in healthy adults: nine studies, 279 participants, moderate overall effect on learning (g=0.50, p=.0001). Biggest gains came when stimulation was applied during the learning phase, not during test.

Balboa-Bandeira et al., Neuropsychologia (2021)
Read the paper
Bar chart showing tES has a larger effect on learning (d=0.712) than on in-the-moment performance (d=0.207)

tES boosts learning more than performance

A meta-analysis of 246 effect sizes from language and math tasks. Stimulation during the learning phase (d=0.712) was more than three times as effective as stimulation during testing (d=0.207), evidence tES drives durable learning, not just an in-the-moment lift.

Simonsmeier et al., Neuroscience and Biobehavioral Reviews (2018)
Read the paper
Bar charts showing active tDCS outperforming sham on low-frequency word errors and non-word reading speed at post-treatment and one-month follow-up

First randomized trial in youth with dyslexia

Eighteen sessions of tDCS paired with cognitive training reduced low-frequency word errors and non-word reading times in children and adolescents with dyslexia. Gains held at one-month follow-up.

Costanzo et al., Restorative Neurology and Neuroscience (2016)
Read the paper
Four-panel bar charts showing anodal tDCS conditions (LA/RSh, LA/RC) outperforming baseline and sham on auditory temporal processing, speech-in-noise perception, verbal memory, and reading

Reading gains tracked auditory-processing gains

Anodal tDCS over left superior temporal gyrus in dyslexic children improved auditory temporal processing, speech-in-noise perception, verbal memory, and reading, with reading improvements statistically tied to the underlying auditory gains.

Rahimi et al., Neuropsychologia (2022)
Read the paper
Short protocol

Five daily sessions, effects held at a month

A crossover trial in 24 children and adolescents with dyslexia: five consecutive daily tDCS sessions produced non-word reading speed gains sustained at one-month follow-up, evidence a short, deployable protocol is enough.

Battisti et al., Frontiers in Psychology (2022)
Read the paper
Safety

Industry safety consensus for limited-output tES

Expert consensus on safe output parameters for transcranial electrical stimulation in wellness, over-the-counter, and consumer applications, the standard our protocol sits inside.

Bikson et al., Brain Stimulation (2023)
Read the paper

Pilot partners

Currently recruiting at Golden Advantage Education.

Golden Advantage Education's team of specialists delivers Orton-Gillingham structured-literacy instruction to students with dyslexia and other learning differences. Jennifer Golden founded the center in 2010; she has been a Certified Orton-Gillingham Specialist since 2003, and is also a Reading Specialist and Special Education Teacher. Golden Advantage is the site of our pediatric reading pilot.

goldenadvantageeducation.com
Jennifer Golden

Jennifer Golden

Founder · Montvale, NJ

The device

Where we started, and where the next model is going.

Original General Neuroscience tES prototype: a black headband holding electrodes, a small enclosure with onboard electronics, and a status indicator

Original prototype

The “Citizen Science” Kickstarter Headset.

Next-generation General Neuroscience tES headset: an orange 3D-printed band with sponge electrodes, held toward the camera

Next-generation build

A much improved beta NeuroLingo Pro, with adjustable targeting.

A General Neuroscience team member wearing the orange HAX-branded tES headset in the lab

In the lab

A beta NeuroLingo Pro in stimulation and comfort testing.

The team

Our team combines Yale Neuroscience with Electrical, Mechanical, and Computer Engineers.

Dr. Alec Sheffield

Dr. Alec Sheffield

CEO & Chief Scientific Officer

Yale-trained neuroscientist (PhD, 2025). Expertise in non-invasive brain stimulation and electrophysiology.

Currently learningMandarin Chinese

Luke Knoble

Luke Knoble

Chief Technology Officer

Ex-Boeing, then to Penumbra building embedded software for stroke-rehabilitation devices. Leads development of the Neurolingo System.

William Polsky

William Polsky

Chief Operations Officer

Mechanical engineer out of the New Haven startup community. Runs design, supply, and manufacturing.

Currently learningItalian

Zida Sung

Zida Sung

Principal Electrical Engineer

Specialist in low-power circuit design. Owns the non-invasive brain stimulation circuitry.

Vanacharla Bhaskara

Vanacharla Bhaskara

Software Engineering Intern

Master's in Data Science. Machine learning specialist.

Currently learningEsoteric English vocabulary

CZ Martin

Senior Software Engineer

Machine learning specialist and full stack engineer. Virginia Tech, 2019.

Currently learningVietnamese

Advisors

Clinical and educational guidance.

Dr. Joseph Knoble, M.D.

Dr. Joseph Knoble, M.D.

Chief Medical Advisor

Former Chief Fellow at Yale Psychiatry. Clinical safety advisor for the NeuroLingo System.

Jennifer Golden

Jennifer Golden

Curriculum and Assessment Advisor

Certified Orton-Gillingham Specialist since 2003, Author, Reading Specialist, and Special Education Teacher. Founder of Golden Advantage Education.

The company

A benefit-corporation running IRB-reviewed pilots for those of us who struggle with language.

General Neuroscience designs and manufactures its own transcranial electrical stimulation hardware and runs it under protocols reviewed by WCG. More than 200 people have used the NeuroLingo to date.

Oversight

Our pilot protocols are reviewed by WCG, an independent institutional review board.

Investigational device · not FDA-cleared
Funding and manufacturing

SOSV is our institutional investor. Its hardware program, HAX, helps manufacture our headsets, the same program behind Formlabs, Opentrons, Neurode, Samphire Neuro, and Flow Neuro. We came out of the Tsai Center for Innovative Thinking at Yale (Tsai CITY).

HAX · SOSV
Pilot sites

We are enrolling now at Golden Advantage Education, an Orton-Gillingham structured-literacy center in Montvale, New Jersey. Two further sites, a university intensive English program and a research-university neurostimulation lab, will be named as each partner is ready.

Montvale, NJ · two sites to be announced